CURRENT AND FUTURE THERAPEUTIC STRATEGIES FOR HIGH-GRADE GLIOMAS LEVERAGING THE INTERPLAY BETWEEN EPIGENETIC REGULATORS AND KINASE SIGNALING NETWORKS

Current and future therapeutic strategies for high-grade gliomas leveraging the interplay between epigenetic regulators and kinase signaling networks

Abstract Targeted therapies, including small molecule inhibitors directed against aberrant kinase signaling and chromatin regulators, are emerging treatment options for high-grade gliomas (HGG).However, when translating these inhibitors into the clinic, their efficacy is generally limited to partial and transient responses.Recent studies in models

read more


Surrogate cardiovascular outcomes with sodium-glucose co-transporter-2 inhibitors in women: An updated meta-analysis

The burden of cardiovascular disease morbidity and mortality among women with type 2 diabetes mellitus remains high, despite the improvement in therapeutic management over the recent years.Sodium-glucose co-transporter-2 (SGLT-2) inhibitors have revolutionized treatment of cardiovascular disease in subjects with diabetes.However, previous meta-anal

read more

Depression, anxiety, and stress in partners of Australian combat veterans and military personnel: a comparison with Australian population norms

Partners of Australian combat veterans are at an increased risk of experiencing mental health problems.The present study provides a comparative analysis of the mental health of partners of veterans with that of the Australian normative data.To compare different types of groups of partners, the study samples comprised: (a) partners of Australian com

read more